Title : Pharmacologic Characterization of JNJ-42226314, [1-(4-Fluorophenyl)indol-5-yl]-[3-[4-(thiazole-2-carbonyl)piperazin-1-yl]azetidin-1-yl]methanone, a Reversible, Selective, and Potent Monoacylglycerol Lipase Inhibitor.

Pub. Date : 2020 Mar

PMID : 31818916






3 Functional Relationships(s)
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1 Inhibition of 2-AG degradation leads to elevation of 2-AG, the most abundant endogenous agonist of the cannabinoid receptors (CBs) CB1 and CB2. glyceryl 2-arachidonate cannabinoid receptor 1 Homo sapiens
2 Inhibition of 2-AG degradation leads to elevation of 2-AG, the most abundant endogenous agonist of the cannabinoid receptors (CBs) CB1 and CB2. glyceryl 2-arachidonate cannabinoid receptor 1 Homo sapiens
3 In rodent brain, the compound time- and dose-dependently bound to MAGL, indirectly led to CB1 occupancy by raising 2-AG levels, and raised norepinephrine levels in cortex. glyceryl 2-arachidonate cannabinoid receptor 1 Homo sapiens