Pub. Date : 2020 Jan
PMID : 31816435
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The influence of metformin on IGF-1 levels in humans: A systematic review and meta-analysis. | Metformin | insulin like growth factor 1 | Homo sapiens |
| 2 | BACKGROUND: A meta-analysis is needed to comprehensively consolidate findings from the influence of metformin on IGF-1 levels. | Metformin | insulin like growth factor 1 | Homo sapiens |
| 3 | The present study was conducted with the objective to accurately evaluate the influence of metformin intake on IGF-1 levels via a meta-analysis of randomized controlled trials. | Metformin | insulin like growth factor 1 | Homo sapiens |
| 4 | Weighted mean difference (WMD) with the 95 % CI were applied for estimating the effects of metformin on serum IGF-1 levels. | Metformin | insulin like growth factor 1 | Homo sapiens |
| 5 | Pooled results demonstrated an overall non-significant decline in IGF-1 following metformin intake (WMD: -8.292 ng/ml, 95 % CI: -20.248, 3.664, p = 0.174) with heterogeneity among (p = 0.000,I2 = 87.1 %). | Metformin | insulin like growth factor 1 | Homo sapiens |
| 6 | Moreover, in age 18 < years older metformin intake (WMD: 15.125 ng/ml, 95 % CI: 5.522, 24.729, I2 = 92.5 %) significantly increased IGF-1 than 18 <= years older (WMD:-1.038 ng/ml, 95 % CI: -3.578,1.502,I2 = 78.0 %). | Metformin | insulin like growth factor 1 | Homo sapiens |
| 7 | Following dose-response evaluation, metformin intake reduced IGF-1 (coefficient for dose-response analysis= -13.14, P = 0.041 and coefficient for liner analysis= -0.066, P = 0.038) significantly based on treatment duration. | Metformin | insulin like growth factor 1 | Homo sapiens |
| 8 | CONCLUSION: We found in children, intervention duration <12 weeks yielded significant reductions in IGF-1, whilst paradoxically, in participants >18 years old, metformin intake significantly increased IGF-1. | Metformin | insulin like growth factor 1 | Homo sapiens |