PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31816435-0	2020	The influence of metformin on IGF-1 levels in humans: A systematic review and meta-analysis.	Metformin	17-26	insulin like growth factor 1	Homo sapiens	30-35	
31816435-1	2020	BACKGROUND: A meta-analysis is needed to comprehensively consolidate findings from the influence of metformin on IGF-1 levels.	Metformin	100-109	insulin like growth factor 1	Homo sapiens	113-118	
31816435-2	2020	The present study was conducted with the objective to accurately evaluate the influence of metformin intake on IGF-1 levels via a meta-analysis of randomized controlled trials.	Metformin	91-100	insulin like growth factor 1	Homo sapiens	111-116	
31816435-4	2020	Weighted mean difference (WMD) with the 95 % CI were applied for estimating the effects of metformin on serum IGF-1 levels.	Metformin	91-100	insulin like growth factor 1	Homo sapiens	110-115	
31816435-6	2020	Pooled results demonstrated an overall non-significant decline in IGF-1 following metformin intake (WMD: -8.292 ng/ml, 95 % CI: -20.248, 3.664, p = 0.174) with heterogeneity among (p = 0.000,I2 = 87.1 %).	Metformin	82-91	insulin like growth factor 1	Homo sapiens	66-71	
31816435-8	2020	Moreover, in age 18 < years older metformin intake (WMD: 15.125 ng/ml, 95 % CI: 5.522, 24.729, I2 = 92.5 %) significantly increased IGF-1 than 18 <= years older (WMD:-1.038 ng/ml, 95 % CI: -3.578,1.502,I2 = 78.0 %).	Metformin	34-43	insulin like growth factor 1	Homo sapiens	132-137	
31816435-9	2020	Following dose-response evaluation, metformin intake reduced IGF-1 (coefficient for dose-response analysis= -13.14, P = 0.041 and coefficient for liner analysis= -0.066, P = 0.038) significantly based on treatment duration.	Metformin	36-45	insulin like growth factor 1	Homo sapiens	61-66	
31816435-10	2020	CONCLUSION: We found in children, intervention duration <12 weeks yielded significant reductions in IGF-1, whilst paradoxically, in participants >18 years old, metformin intake significantly increased IGF-1.	Metformin	160-169	insulin like growth factor 1	Homo sapiens	201-206