Pub. Date : 2019 Dec 7
PMID : 31811815
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Melatonin protects blood-brain barrier integrity and permeability by inhibiting matrix metalloproteinase-9 via the NOTCH3/NF-kappaB pathway. | Melatonin | matrix metallopeptidase 9 | Homo sapiens |
| 2 | Melatonin also downregulated MMP-9 and upregulated tissue inhibitor of metalloproteinases 1 (TIMP-1) gene expression, which decreased the MMP-9/TIMP-1 ratio. | Melatonin | matrix metallopeptidase 9 | Homo sapiens |
| 3 | Melatonin also downregulated MMP-9 and upregulated tissue inhibitor of metalloproteinases 1 (TIMP-1) gene expression, which decreased the MMP-9/TIMP-1 ratio. | Melatonin | matrix metallopeptidase 9 | Homo sapiens |
| 4 | Our results suggest that melatonin reduced MMP-9-induced permeability of the BBB. | Melatonin | matrix metallopeptidase 9 | Homo sapiens |
| 5 | Melatonin reduced MMP-9 expression and activity, which was induced by IL-1beta through the regulation of the NOTCH3/NF-kappaB signaling pathway in pericytes, suggesting that pericytes regulate BBB integrity and function. | Melatonin | matrix metallopeptidase 9 | Homo sapiens |