Pub. Date : 2020 Mar
PMID : 31810748
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The antidepressant-like effects of fluvoxamine in mice involve the mTOR signaling in the hippocampus and prefrontal cortex. | Fluvoxamine | mechanistic target of rapamycin kinase | Mus musculus |
| 2 | Therefore, this study aims to evaluate whether mTOR underlies the antidepressant-like effects of fluvoxamine. | Fluvoxamine | mechanistic target of rapamycin kinase | Mus musculus |
| 3 | It was found that fluvoxamine treatment fully reversed the effects of CUMS on the mTOR signaling in the hippocampus and PFC, and the usage of rapamycin significantly prevented the antidepressant-like effects of fluvoxamine in the CUMS model of depression. | Fluvoxamine | mechanistic target of rapamycin kinase | Mus musculus |
| 4 | Taken together, the mTOR system is involved in the antidepressant mechanisms of fluvoxamine. | Fluvoxamine | mechanistic target of rapamycin kinase | Mus musculus |