Title : Melatonin and Rapamycin Attenuate Isoflurane-Induced Cognitive Impairment Through Inhibition of Neuroinflammation by Suppressing the mTOR Signaling in the Hippocampus of Aged Mice.

Pub. Date : 2019

PMID : 31803045






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1 Melatonin and rapamycin significantly ameliorated the isoflurane-induced cognitive impairment and also led to a decrease in the melatonin levels as well as the expression levels of TNF-alpha, IL-1beta, IL-6, and p-mTOR in the hippocampus. Sirolimus interleukin 6 Mus musculus