Title : Discovery of novel 9-heterocyclyl substituted 9H-purines as L858R/T790M/C797S mutant EGFR tyrosine kinase inhibitors.

Pub. Date : 2020 Jan 15

PMID : 31787359






1 Functional Relationships(s)
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1 The introduction of extra hydrogen bond interaction with mutant Ser797 is efficient method for the design of the fourth-generation EGFR-TKIs. Hydrogen epidermal growth factor receptor Homo sapiens