Title : Heterozygous deletion of Seipin in islet beta cells of male mice has an impact on insulin synthesis and secretion through reduced PPARĪ³ expression.

Pub. Date : 2020 Feb

PMID : 31776610






1 Functional Relationships(s)
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1 Ovariectomised female Seipin+/- mice displayed glucose intolerance and deficits in insulin synthesis and secretion, with a decline in islet PPARgamma level; these deleterious effects were reversed by administration of oestradiol or rosiglitazone. Rosiglitazone peroxisome proliferator activated receptor gamma Mus musculus