Pub. Date : 2019 Dec
PMID : 31772646
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Icariin reduces high glucose-induced endothelial progenitor cell dysfunction via inhibiting the p38/CREB pathway and activating the Akt/eNOS/NO pathway. | icariin | mitogen activated protein kinase 14 | Rattus norvegicus |
| 2 | Furthermore, icariin significantly suppressed HG-induced p38 and cAMP response element binding protein (CREB) phosphorylation in EPCs (FC: 1.84+-0.21, P=0.0238 vs. HG group for p38; FC: 2.24+-0.15, P=0.0068 vs. HG group for CREB). | icariin | mitogen activated protein kinase 14 | Rattus norvegicus |
| 3 | Furthermore, icariin significantly suppressed HG-induced p38 and cAMP response element binding protein (CREB) phosphorylation in EPCs (FC: 1.84+-0.21, P=0.0238 vs. HG group for p38; FC: 2.24+-0.15, P=0.0068 vs. HG group for CREB). | icariin | mitogen activated protein kinase 14 | Rattus norvegicus |
| 4 | In conclusion, icariin attenuated HG-induced EPC dysfunction, which may be partially attributed to the inhibition of the p38/CREB pathway and the activation of the Akt/eNOS/NO pathway. | icariin | mitogen activated protein kinase 14 | Rattus norvegicus |