Title : Hepatic insulin resistance induced by mitochondrial oxidative stress can be ameliorated by sphingosine 1-phosphate.

Pub. Date : 2020 Feb 5

PMID : 31759099






1 Functional Relationships(s)
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1 We found that treatment of the normal human liver cell LO2 with 1000 nM insulin for 48 h reduced glucose uptake and increased serine phosphorylation of insulin receptor substrate-1, indicating a reduction in insulin receptor signaling. Serine insulin Homo sapiens