Pub. Date : 2020 Jan
PMID : 31746350
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Salinomycin and its derivatives as potent RET transcriptional inhibitors for the treatment of medullary thyroid carcinoma. | salinomycin | ret proto-oncogene | Homo sapiens |
| 2 | The present study reports the first preclinical characterization of salinomycin and selected analogs as potent RET transcriptional inhibitors. | salinomycin | ret proto-oncogene | Homo sapiens |
| 3 | Reverse transcription-PCR and immunoblotting revealed that salinomycin profoundly decreased RET expression in the TT human MTC cell line by inhibiting RET transcription. | salinomycin | ret proto-oncogene | Homo sapiens |
| 4 | Reverse transcription-PCR and immunoblotting revealed that salinomycin profoundly decreased RET expression in the TT human MTC cell line by inhibiting RET transcription. | salinomycin | ret proto-oncogene | Homo sapiens |
| 5 | Moreover, salinomycin resulted in remarkable anti-proliferative activity against MTC that is driven by RET (gain of function mutation) by selectively inhibiting the intracellular PI3K/Akt/mTOR signaling pathway. | salinomycin | ret proto-oncogene | Homo sapiens |
| 6 | Some of the salinomycin derivatives showed the ability to reduce RET expression where others fail to alter RET expression. | salinomycin | ret proto-oncogene | Homo sapiens |
| 7 | These results suggest that the RET-suppressing effect of salinomycin may be largely attributed to disruption of the Wnt pathway, presumably through interference with the ternary LRP6-Frizzled-Wnt complex. | salinomycin | ret proto-oncogene | Homo sapiens |