Title : Theory Demonstrated a "Coupled" Mechanism for O2 Activation and Substrate Hydroxylation by Binuclear Copper Monooxygenases.

Pub. Date : 2019 Dec 18

PMID : 31746191






1 Functional Relationships(s)
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1 Multiscale simulations have been performed to address the longstanding issue of the "dioxygen activation" by the binucle-ar copper monooxygenases (PHM and DbetaM), which were traditionally classified as the "noncoupled" binuclear copper enzymes. Oxygen peptidylglycine alpha-amidating monooxygenase Homo sapiens