Title : Glycolaldehyde induces sensory neuron death through activation of the c-Jun N-terminal kinase and p-38 MAP kinase pathways.

Pub. Date : 2020 Feb

PMID : 31734714






4 Functional Relationships(s)
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1 Treatment with 500 microM GA significantly up-regulated the phosphorylation of c-jun N-terminal kinase (JNK) and p-38 mitogen-activated kinase (p-38 MAPK) in ND7/23 cells. glycolaldehyde mitogen-activated protein kinase 8 Mus musculus
2 Treatment with 500 microM GA significantly up-regulated the phosphorylation of c-jun N-terminal kinase (JNK) and p-38 mitogen-activated kinase (p-38 MAPK) in ND7/23 cells. glycolaldehyde mitogen-activated protein kinase 8 Mus musculus
3 Furthermore, GA-induced ND7/23 cell death was significantly inhibited due to co-treatment with 10 microM of the JNK inhibitor SP600125 or the p-38 MAPK inhibitor SB239063. glycolaldehyde mitogen-activated protein kinase 8 Mus musculus
4 These findings suggest the involvement of JNK and p-38 MAPK-signaling pathways in GA-induced neuronal cell death and that enhanced GA production under diabetic conditions might be involved in the pathogenesis of diabetic neuropathy. glycolaldehyde mitogen-activated protein kinase 8 Mus musculus