Pub. Date : 2019 Nov 15
PMID : 31729451
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Aspirin suppresses chemoresistance and enhances antitumor activity of 5-Fu in 5-Fu-resistant colorectal cancer by abolishing 5-Fu-induced NF-kappaB activation. | Fluorouracil | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | Aspirin suppresses chemoresistance and enhances antitumor activity of 5-Fu in 5-Fu-resistant colorectal cancer by abolishing 5-Fu-induced NF-kappaB activation. | Fluorouracil | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | Aspirin suppresses chemoresistance and enhances antitumor activity of 5-Fu in 5-Fu-resistant colorectal cancer by abolishing 5-Fu-induced NF-kappaB activation. | Fluorouracil | nuclear factor kappa B subunit 1 | Homo sapiens |
| 4 | In vivo, aspirin markedly enhanced the antitumor activity of 5-Fu in suppressing tumor growth and metastasis, and down-regulating the expression of NF-kappaB-regulated genes in the 5-Fu-resistant cells. | Fluorouracil | nuclear factor kappa B subunit 1 | Homo sapiens |
| 5 | Obviously, aspirin completely eradicated the 5-Fu-induced NF-kappaB activation, without inducing pronounced adverse effects. | Fluorouracil | nuclear factor kappa B subunit 1 | Homo sapiens |
| 6 | Taken together, findings in this study suggest that aspirin can reverse chemoresistance and potentiate the antitumor effect of 5-Fu, which is achieved through abolishing the 5-Fu-induced NF-kappaB activation, suggesting that aspirin may be a promising adjuvant therapeutic agent for CRC. | Fluorouracil | nuclear factor kappa B subunit 1 | Homo sapiens |
| 7 | Taken together, findings in this study suggest that aspirin can reverse chemoresistance and potentiate the antitumor effect of 5-Fu, which is achieved through abolishing the 5-Fu-induced NF-kappaB activation, suggesting that aspirin may be a promising adjuvant therapeutic agent for CRC. | Fluorouracil | nuclear factor kappa B subunit 1 | Homo sapiens |