Title : Plant sphingolipids promote extracellular vesicle release and alleviate amyloid-β pathologies in a mouse model of Alzheimer's disease.

Pub. Date : 2019 Nov 14

PMID : 31727994






3 Functional Relationships(s)
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1 Oral administration of plant glucosylceramide (GlcCer) to APP overexpressing mice markedly reduced Abeta levels and plaque burdens and improved cognition in a Y-maze learning task. Glucosylceramides amyloid beta (A4) precursor protein Mus musculus
2 Oral administration of plant glucosylceramide (GlcCer) to APP overexpressing mice markedly reduced Abeta levels and plaque burdens and improved cognition in a Y-maze learning task. Glucosylceramides amyloid beta (A4) precursor protein Mus musculus
3 Moreover, there were substantial increases in the neuronal marker NCAM-1, L1CAM, and Abeta in EVs isolated from serum and brain tissues of the GlcCer-treated AD model mice. Glucosylceramides amyloid beta (A4) precursor protein Mus musculus