Title : Glucuronidation of Abiraterone and Its Pharmacologically Active Metabolites by UGT1A4, Influence of Polymorphic Variants and Their Potential as Inhibitors of Steroid Glucuronidation.

Pub. Date : 2020 Feb

PMID : 31727674






6 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Abiraterone acetate (AA) is a prodrug of abiraterone (Abi), a CYP17A1 inhibitor used to treat patients with advanced prostate cancer (PCa). abiraterone cytochrome P450 family 17 subfamily A member 1 Homo sapiens
2 Abiraterone acetate (AA) is a prodrug of abiraterone (Abi), a CYP17A1 inhibitor used to treat patients with advanced prostate cancer (PCa). abiraterone cytochrome P450 family 17 subfamily A member 1 Homo sapiens
3 SIGNIFICANCE STATEMENT: The antiandrogen abiraterone (Abi) is a selective steroidal inhibitor of the cytochrome P450 17alpha-hydroxy/17,20-lyase (CYP17A1), an enzyme involved in the biosynthesis of androgens. abiraterone cytochrome P450 family 17 subfamily A member 1 Homo sapiens
4 SIGNIFICANCE STATEMENT: The antiandrogen abiraterone (Abi) is a selective steroidal inhibitor of the cytochrome P450 17alpha-hydroxy/17,20-lyase (CYP17A1), an enzyme involved in the biosynthesis of androgens. abiraterone cytochrome P450 family 17 subfamily A member 1 Homo sapiens
5 SIGNIFICANCE STATEMENT: The antiandrogen abiraterone (Abi) is a selective steroidal inhibitor of the cytochrome P450 17alpha-hydroxy/17,20-lyase (CYP17A1), an enzyme involved in the biosynthesis of androgens. abiraterone cytochrome P450 family 17 subfamily A member 1 Homo sapiens
6 SIGNIFICANCE STATEMENT: The antiandrogen abiraterone (Abi) is a selective steroidal inhibitor of the cytochrome P450 17alpha-hydroxy/17,20-lyase (CYP17A1), an enzyme involved in the biosynthesis of androgens. abiraterone cytochrome P450 family 17 subfamily A member 1 Homo sapiens