Pub. Date : 1988 Oct 25
PMID : 3170604
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The inhibitions of protein synthesis initiation in heme-deficient reticulocyte lysates and in GSSG-treated hemin-supplemented lysates are both characterized by the activation of heme-regulated eIF-2 alpha kinase, which phosphorylates the alpha-subunit of eukaryotic initiation factor (eIF-2). | Glutathione Disulfide | eukaryotic translation initiation factor 2 subunit beta | Homo sapiens |
| 2 | The inhibitions of protein synthesis initiation in heme-deficient reticulocyte lysates and in GSSG-treated hemin-supplemented lysates are both characterized by the activation of heme-regulated eIF-2 alpha kinase, which phosphorylates the alpha-subunit of eukaryotic initiation factor (eIF-2). | Glutathione Disulfide | eukaryotic translation initiation factor 2 subunit beta | Homo sapiens |
| 3 | RF inactivation in GSSG-induced inhibition appears to be due to two separate but additive effects: (i) the formation of the phosphorylated 15 S RF complex, RF.eIF-2(alpha P), and (ii) the formation of disulfide complexes which inhibit RF activity. | Glutathione Disulfide | eukaryotic translation initiation factor 2 subunit beta | Homo sapiens |
| 4 | RF inactivation in GSSG-induced inhibition appears to be due to two separate but additive effects: (i) the formation of the phosphorylated 15 S RF complex, RF.eIF-2(alpha P), and (ii) the formation of disulfide complexes which inhibit RF activity. | Glutathione Disulfide | eukaryotic translation initiation factor 2 subunit beta | Homo sapiens |