Pub. Date : 2020 Jan
PMID : 31702064
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The effect of metoprolol on the expression of miR-1 and connexin43 (Cx43) was quantified by real-time PCR and western blot, respectively. | Metoprolol | gap junction protein, alpha 1 | Rattus norvegicus |
| 2 | The effect of metoprolol on the expression of miR-1 and connexin43 (Cx43) was quantified by real-time PCR and western blot, respectively. | Metoprolol | gap junction protein, alpha 1 | Rattus norvegicus |
| 3 | Metoprolol reversed the up-regulation of miR-1 and down-regulation of Cx43 in MI heart. | Metoprolol | gap junction protein, alpha 1 | Rattus norvegicus |
| 4 | Moreover, in H2 O2 -stimulated cardiomyocytes, overexpression of miR-1 abolished the effects of metoprolol on Cx43 up-regulation and increased intercellular communication, indicating that miR-1 may be a necessary mediator for the cardiac protective function of metoprolol. | Metoprolol | gap junction protein, alpha 1 | Rattus norvegicus |
| 5 | Moreover, in H2 O2 -stimulated cardiomyocytes, overexpression of miR-1 abolished the effects of metoprolol on Cx43 up-regulation and increased intercellular communication, indicating that miR-1 may be a necessary mediator for the cardiac protective function of metoprolol. | Metoprolol | gap junction protein, alpha 1 | Rattus norvegicus |
| 6 | CONCLUSIONS: Metoprolol relieves MI injury via suppression miR-1, thus increasing its target protein Cx43 and improving intercellular communication. | Metoprolol | gap junction protein, alpha 1 | Rattus norvegicus |