Pub. Date : 2019 Oct
PMID : 31694081
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | PF-04620110, a Potent Antidiabetic Agent, Suppresses Fatty Acid-Induced NLRP3 Inflammasome Activation in Macrophages. | Fatty Acids | NLR family, pyrin domain containing 3 | Mus musculus |
| 2 | RESULTS: Here we show that PF-04620110 suppressed fatty acid-induced nucleotide-binding domain, leucine-rich-repeat-containing receptor (NLR), pyrin-domain-containing 3 (NLRP3) inflammasome activation in macrophages. | Fatty Acids | NLR family, pyrin domain containing 3 | Mus musculus |
| 3 | Furthermore, genetic inhibition of DGAT1 suppressed fatty acid-induced NLRP3 inflammasome activation. | Fatty Acids | NLR family, pyrin domain containing 3 | Mus musculus |
| 4 | CONCLUSION: Our results suggest that PF-04620110 suppresses fatty acid-induced NLRP3 inflammasome activation. | Fatty Acids | NLR family, pyrin domain containing 3 | Mus musculus |