Pub. Date : 2019 Nov 1
PMID : 31683916
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Identifying Metabolic Perturbations and Toxic Effects of Rac-Metalaxyl and Metalaxyl-M in Mice Using Integrative NMR and UPLC-MS/MS Based Metabolomics. | metalaxyl | thymoma viral proto-oncogene 1 | Mus musculus |
| 2 | Although metabolic perturbations are sensitive indicators for low-dose toxic effects, the metabolic mechanisms affected by rac-metalaxyl and metalaxyl-M in mammals from a metabolic profiling perspective remain unclear. | metalaxyl | thymoma viral proto-oncogene 1 | Mus musculus |
| 3 | In this study, the metabolic perturbations and toxic effects of rac-metalaxyl and metalaxyl-M in mice were carefully investigated using integrative nuclear magnetic resonance (NMR) and ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) based metabolomics. | metalaxyl | thymoma viral proto-oncogene 1 | Mus musculus |
| 4 | Histopathology, NMR-based untargeted urine profile, multivariate pattern recognition, metabolite identification, pathway analysis, UPLC-MS/MS based targeted serum amino acids, and tryptophan pathway analysis were determined after rac-metalaxyl and metalaxyl-M exposure, individually. | metalaxyl | thymoma viral proto-oncogene 1 | Mus musculus |
| 5 | The metabolic perturbations induced by rac-metalaxyl and metalaxyl-M were directly separated using partial least-squares discriminant analysis (PLS-DA). | metalaxyl | thymoma viral proto-oncogene 1 | Mus musculus |
| 6 | Serum amino acids and tryptophan pathway metabolite changes induced by rac-metalaxyl and metalaxyl-M were also different even at the same exposure level. | metalaxyl | thymoma viral proto-oncogene 1 | Mus musculus |
| 7 | Such results may provide specific insight into the metabolic perturbations and toxic effects of rac-metalaxyl and metalaxyl-M, and contribute to providing available data for health risk assessments of rac-metalaxyl and metalaxyl-M at a metabolomics level. | metalaxyl | thymoma viral proto-oncogene 1 | Mus musculus |