Pub. Date : 2019
PMID : 31680965
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study, we reported for the first time that phillyrin (Phil), an active ingredient extracted from forsythia, significantly inhibited RANKL-induced osteoclastogenesis and bone resorption in vitro and protected against lipopolysaccharide-induced osteolysis in vivo. | phillyrin | tumor necrosis factor (ligand) superfamily, member 11 | Mus musculus |
| 2 | In this study, we reported for the first time that phillyrin (Phil), an active ingredient extracted from forsythia, significantly inhibited RANKL-induced osteoclastogenesis and bone resorption in vitro and protected against lipopolysaccharide-induced osteolysis in vivo. | phillyrin | tumor necrosis factor (ligand) superfamily, member 11 | Mus musculus |
| 3 | Further molecular investigations demonstrated that Phil effectively blocked RANKL-induced activations of c-Jun N-terminal kinase and extracellular signal-regulated kinase, which suppressed the expression of c-Fos and nuclear factor of activated T-cells cytoplasmic 1. | phillyrin | tumor necrosis factor (ligand) superfamily, member 11 | Mus musculus |