Title : Selective activation of estrogen receptor β alleviates cerebral ischemia neuroinflammatory injury.

Pub. Date : 2020 Jan 1

PMID : 31676226






1 Functional Relationships(s)
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1 We found that 8mg/kg DPN (ERbeta-specific agonist) replacement therapy (3 weeks) to the ovariectomized (OVX) mice significantly reduced ischemia injury and alleviated microglia and astrocyte activation, and markedly inhibited the expression of NF-kappaB and proinflammatory cytokines (TNF-alpha, IL-1beta, and IL-6). NAD interleukin 6 Mus musculus