Title : Unique surface-exposed hydrophobic residues in the C1 domain of factor VIII contribute to cofactor function and von Willebrand factor binding.

Pub. Date : 2020 Feb

PMID : 31675465






2 Functional Relationships(s)
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Protein Name
Organism
1 The identified residues were replaced into alanine residues to identify their role in FIXa and VWF interaction. Alanine von Willebrand factor Homo sapiens
2 Substitution into alanine of the also surface-exposed V2125, which is spatially next to F2127, affected only VWF binding. Alanine von Willebrand factor Homo sapiens