Title : Nuclear Factor Erythroid-Derived 2-Like 2-Induced Reductive Stress Favors Self-Renewal of Breast Cancer Stem-Like Cells via the FoxO3a-Bmi-1 Axis.

Pub. Date : 2020 Jun

PMID : 31672029






1 Functional Relationships(s)
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1 CONCLUSIONS: Nrf2 overactivation in breast CSCs, which, in turn, upregulate GCLC expression and consequently enhances GSH biosynthesis with concurrent reduction in intracellular ROS accumulation, provoking the reductive stress. Glutathione NFE2 like bZIP transcription factor 2 Homo sapiens