Title : Heme oxygenase-1 dampens the macrophage sterile inflammasome response and regulates its components in the hypoxic lung.

Pub. Date : 2020 Jan 1

PMID : 31664855






1 Functional Relationships(s)
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1 The production of cleaved IL-1B and the activation of caspase-1 in LPS- and ATP-primed macrophages were inhibited by hemin, an HO-1 inducer, and two HO-1 enzymatic products [bilirubin and carbon monoxide (CO)]. Bilirubin caspase 1 Mus musculus