Pub. Date : 2019
PMID : 31662771
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | SOD2 Mediates Curcumin-Induced Protection against Oxygen-Glucose Deprivation/Reoxygenation Injury in HT22 Cells. | Curcumin | superoxide dismutase 2, mitochondrial | Mus musculus |
| 2 | The aim of this study is to explore the potential neuroprotective mechanism of curcumin against oxygen-glucose deprivation/reoxygenation (OGD/R) injury in HT22 cells and investigate whether type-2 superoxide dismutase (SOD2) is involved in the curcumin-induced protection. | Curcumin | superoxide dismutase 2, mitochondrial | Mus musculus |
| 3 | Meanwhile, coadministration of 100 ng/ml curcumin reduced the cell injury and apoptosis, inhibited intracellular ROS and mitochondrial superoxide accumulation, and ameliorated intracellular SOD2, cell morphology, MMP, and mitochondrial complex I activity. | Curcumin | superoxide dismutase 2, mitochondrial | Mus musculus |
| 4 | Downregulating the SOD2 expression by using siRNA, however, significantly reversed the curcumin-induced cytoprotection (P < 0.05). | Curcumin | superoxide dismutase 2, mitochondrial | Mus musculus |