Pub. Date : 2019 Dec
PMID : 31661303
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Based on our previous studies, we hypothesized that glutamate released during seizures activates cytosolic phospholipase A2 (cPLA2), resulting in P-gp and BCRP overexpression. | Glutamic Acid | ATP-binding cassette, subfamily B (MDR/TAP), member 1B | Rattus norvegicus |
| 2 | Glutamate increased cPLA2, P-gp, and BCRP protein and activity levels in isolated brain capillaries. | Glutamic Acid | ATP-binding cassette, subfamily B (MDR/TAP), member 1B | Rattus norvegicus |
| 3 | Our data support the hypothesis that glutamate signals cPLA2 activation, resulting in overexpression of blood-brain barrier P-gp and BCRP.-Hartz, A. M. S., Rempe, R. G., Soldner, E. L. B., Pekcec, A., Schlichtiger, J., Kryscio, R., Bauer, B. | Glutamic Acid | ATP-binding cassette, subfamily B (MDR/TAP), member 1B | Rattus norvegicus |