Pub. Date : 2019 Oct 30
PMID : 31657440
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | They are known to be oxidized to NAD(P)+ by mammalian renalase, an FAD-linked enzyme mainly present in heart and kidney, and by related bacterial enzymes. | NAD | renalase, FAD dependent amine oxidase | Homo sapiens |
| 2 | Inactivation of renalase and of PNPO in mammalian cells and of Ygr017w in yeasts led to the accumulation of a reduced form of 6-NADH, tentatively identified as 4,5,6-NADH3, which can also be produced in vitro by reduction of 6-NADH by glyceraldehyde-3-phosphate dehydrogenase or glucose-6-phosphate dehydrogenase. | NAD | renalase, FAD dependent amine oxidase | Homo sapiens |
| 3 | Inactivation of renalase and of PNPO in mammalian cells and of Ygr017w in yeasts led to the accumulation of a reduced form of 6-NADH, tentatively identified as 4,5,6-NADH3, which can also be produced in vitro by reduction of 6-NADH by glyceraldehyde-3-phosphate dehydrogenase or glucose-6-phosphate dehydrogenase. | NAD | renalase, FAD dependent amine oxidase | Homo sapiens |
| 4 | Inactivation of renalase and of PNPO in mammalian cells and of Ygr017w in yeasts led to the accumulation of a reduced form of 6-NADH, tentatively identified as 4,5,6-NADH3, which can also be produced in vitro by reduction of 6-NADH by glyceraldehyde-3-phosphate dehydrogenase or glucose-6-phosphate dehydrogenase. | NAD | renalase, FAD dependent amine oxidase | Homo sapiens |
| 5 | These findings indicate that two different classes of enzymes using either FAD (renalase) or FMN (PNPOs and PNPO-RPs) as a cofactor play an as yet unsuspected role in removing damaged forms of NAD(P). | NAD | renalase, FAD dependent amine oxidase | Homo sapiens |