Title : PKC Mediates LPS-Induced IL-1β Expression and Participates in the Pro-inflammatory Effect of A2AR Under High Glutamate Concentrations in Mouse Microglia.

Pub. Date : 2019 Dec

PMID : 31650360






2 Functional Relationships(s)
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1 GF109203X, a specific PKC inhibitor, inhibited the LPS-induced expression of IL-1beta messenger ribonucleic acid and intracellular protein in a dose-dependent manner. bisindolylmaleimide I interleukin 1 alpha Mus musculus
2 Moreover, 5 microM GF109203X prevented LPS-induced IL-1beta expression but did not significantly affect LPS-induced TNF-alpha expression. bisindolylmaleimide I interleukin 1 alpha Mus musculus