Pub. Date : 2020 Feb
PMID : 31649333
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here we show that Emei is a novel ER Ca2+ regulator that synergizes with RasV12 to induce tumor growth via JNK-mediated Hippo signaling. | Calcium | mitogen-activated protein kinase 8 | Homo sapiens |
| 2 | Emei disruption reduces ER Ca2+ level and subsequently leads to JNK activation and Hippo inactivation. | Calcium | mitogen-activated protein kinase 8 | Homo sapiens |
| 3 | Together, our findings provide a novel mechanism of tumor growth that acts through intracellular Ca2+ levels to modulate JNK-mediated Hippo signaling. | Calcium | mitogen-activated protein kinase 8 | Homo sapiens |