Title : Brain Targeting of Acyl-CoA:Cholesterol O-Acyltransferase-1 Inhibitor K-604 via the Intranasal Route Using a Hydroxycarboxylic Acid Solution.

Pub. Date : 2019 Oct 15

PMID : 31646241






1 Functional Relationships(s)
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1 An acyl-CoA:cholesterol O-acyltransferase-1 (ACAT-1/SOAT-1) inhibitor, K-604 is a promising drug candidate for the treatment of Alzheimer"s disease and glioblastoma; however, it exhibits poor solubility in neutral water and low permeability across the blood-brain barrier. Acyl Coenzyme A acetyl-Coenzyme A acetyltransferase 1 Mus musculus