Title : Repurposing the aldose reductase inhibitor and diabetic neuropathy drug epalrestat for the congenital disorder of glycosylation PMM2-CDG.

Pub. Date : 2019 Nov 11

PMID : 31636082






1 Functional Relationships(s)
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1 Pharmacological inhibition of aldose reductase by epalrestat may shunt glucose from the polyol pathway to glucose-1,6-bisphosphate, which is an endogenous stabilizer and coactivator of PMM2 homodimerization. polyol aldo-keto reductase family 1 member B Homo sapiens