Title : Renoprotective effect of celecoxib against gentamicin-induced nephrotoxicity through suppressing NFκB and caspase-3 signaling pathways in rats.

Pub. Date : 2020 Jan 5

PMID : 31628940






3 Functional Relationships(s)
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1 The current study aimed to explore the potential protective impacts of celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, on gentamicin-induced nephrotoxicity and the potential mechanisms in rats. celecoxib prostaglandin-endoperoxide synthase 2 Rattus norvegicus
2 The current study aimed to explore the potential protective impacts of celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, on gentamicin-induced nephrotoxicity and the potential mechanisms in rats. celecoxib prostaglandin-endoperoxide synthase 2 Rattus norvegicus
3 In immunohistochemistry, celecoxib-treated rats showed decreased immunoreactivity against COX-2 in tubular cells and a mild positive immunoreactivity against heat shock protein 70 (HSP70) in renal interstitial cells. celecoxib prostaglandin-endoperoxide synthase 2 Rattus norvegicus