Title : Coadministered cannabidiol and clobazam: Preclinical evidence for both pharmacodynamic and pharmacokinetic interactions.

Pub. Date : 2019 Nov

PMID : 31625159






1 Functional Relationships(s)
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1 METHODS: We examined whether CBD inhibits human CYP3A4 and CYP2C19 mediated metabolism of clobazam and N-desmethylclobazam (N-CLB), respectively, and performed studies assessing the effects of CBD on brain and plasma pharmacokinetics of clobazam in mice. Cannabidiol cytochrome P450 family 3 subfamily A member 4 Homo sapiens