Title : Combinatorial targeting of MTHFD2 and PAICS in purine synthesis as a novel therapeutic strategy.

Pub. Date : 2019 Oct 17

PMID : 31624245






1 Functional Relationships(s)
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1 Moreover, we found that MYCN mediated the folate cycle via MTHFD2, which contributed one-carbon unit to enhance purine synthesis, and further regulated nucleotide production by PAICS in response to cancer progression. Folic Acid methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase Homo sapiens