Title : Combinatorial targeting of MTHFD2 and PAICS in purine synthesis as a novel therapeutic strategy.

Pub. Date : 2019 Oct 17

PMID : 31624245

1 Functional Relationships(s)
Compound Name
Protein Name
1 Moreover, we found that MYCN mediated the folate cycle via MTHFD2, which contributed one-carbon unit to enhance purine synthesis, and further regulated nucleotide production by PAICS in response to cancer progression. Folic Acid methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase Homo sapiens