Title : Large-scale conformational rearrangement of the α5-helix of Gα subunits in complex with the guanine nucleotide exchange factor Ric8A.

Pub. Date : 2019 Nov 22

PMID : 31624147






2 Functional Relationships(s)
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1 The resulting interface involved the Galpha alpha5-helix bound to the concave surface of Ric8A and the Galpha beta-sheet that wraps around the C-terminal part of the Ric8A armadillo domain, leading to a severe disruption of the GDP-binding site. Guanosine Diphosphate succinate-CoA ligase GDP/ADP-forming subunit alpha Homo sapiens
2 The resulting interface involved the Galpha alpha5-helix bound to the concave surface of Ric8A and the Galpha beta-sheet that wraps around the C-terminal part of the Ric8A armadillo domain, leading to a severe disruption of the GDP-binding site. Guanosine Diphosphate succinate-CoA ligase GDP/ADP-forming subunit alpha Homo sapiens