Title : The association between maternal nicotine exposure and adipose angiogenesis in female rat offspring: A mechanism of adipose tissue function changes.

Pub. Date : 2020 Jan

PMID : 31622651






4 Functional Relationships(s)
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1 The gene expression of alpha7nAChR, Egr1 and FGF2 was significantly increased in gonadal white adipose tissue (gWAT) and inguinal subcutaneous WAT (igSWAT) of nicotine-exposed females at 4 weeks of age. Nicotine fibroblast growth factor 2 Rattus norvegicus
2 The protein expression of alpha7nAChR, Egr1 and FGF2 was increased in gWAT and igSWAT of nicotine-exposed females at 4 weeks of age, and increased in gWAT at 26 weeks. Nicotine fibroblast growth factor 2 Rattus norvegicus
3 In vitro, nicotine increased the expression of lipid metabolism and alpha7nAChR-Egr1-FGF2 signaling pathway genes/proteins in a concentration- and time-dependent manner. Nicotine fibroblast growth factor 2 Rattus norvegicus
4 Therefore, maternal nicotine exposure promoted the early angiogenesis of adipose tissue via the alpha7nAChR-Egr1-FGF2 signaling pathway, and this angiogenesis mechanism was associated with increased adipogenesis in adipose tissue of female offspring. Nicotine fibroblast growth factor 2 Rattus norvegicus