Pub. Date : 2019 Nov 18
PMID : 31621310
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Isoflavones as Ah Receptor Agonists in Colon-Derived Cell Lines: Structure-Activity Relationships. | Isoflavones | aryl hydrocarbon receptor | Homo sapiens |
| 2 | Therefore, we examined the structure-activity relationships of isoflavones and isomeric flavone and flavanones as AhR ligands on the basis of their induction of CYP1A1, CYP1B1, and UGT1A1 gene expression in colon cancer Caco2 cells and young adult mouse colonocyte (YAMC) cells. | Isoflavones | aryl hydrocarbon receptor | Homo sapiens |
| 3 | The structure-activity relationships for the flavonoids were complex and both response and cell context specific; however, there was significant variability in the AhR activities of the isomeric substituted isoflavones and flavones. | Isoflavones | aryl hydrocarbon receptor | Homo sapiens |
| 4 | In contrast, both 5,7-dihydroxy-4-methoxy substituted isoflavone (biochanin A) and flavone (acacetin) induced all three AhR-responsive genes; 4",5,7-trimethoxyisoflavone was a potent AhR agonist, and the isomeric flavone was AhR-inactive. | Isoflavones | aryl hydrocarbon receptor | Homo sapiens |
| 5 | In contrast, both 5,7-dihydroxy-4-methoxy substituted isoflavone (biochanin A) and flavone (acacetin) induced all three AhR-responsive genes; 4",5,7-trimethoxyisoflavone was a potent AhR agonist, and the isomeric flavone was AhR-inactive. | Isoflavones | aryl hydrocarbon receptor | Homo sapiens |
| 6 | In contrast, both 5,7-dihydroxy-4-methoxy substituted isoflavone (biochanin A) and flavone (acacetin) induced all three AhR-responsive genes; 4",5,7-trimethoxyisoflavone was a potent AhR agonist, and the isomeric flavone was AhR-inactive. | Isoflavones | aryl hydrocarbon receptor | Homo sapiens |
| 7 | These results coupled with simulation studies modeling flavonoid interaction within the AhR binding pocket demonstrate that the orientation of the substituted phenyl ring at C-2 (flavones) or C-3 (isoflavones) on the common 4-H-chromen-4-one ring strongly influences the activities of isoflavones and flavones as AhR agonists. | Isoflavones | aryl hydrocarbon receptor | Homo sapiens |
| 8 | These results coupled with simulation studies modeling flavonoid interaction within the AhR binding pocket demonstrate that the orientation of the substituted phenyl ring at C-2 (flavones) or C-3 (isoflavones) on the common 4-H-chromen-4-one ring strongly influences the activities of isoflavones and flavones as AhR agonists. | Isoflavones | aryl hydrocarbon receptor | Homo sapiens |
| 9 | These results coupled with simulation studies modeling flavonoid interaction within the AhR binding pocket demonstrate that the orientation of the substituted phenyl ring at C-2 (flavones) or C-3 (isoflavones) on the common 4-H-chromen-4-one ring strongly influences the activities of isoflavones and flavones as AhR agonists. | Isoflavones | aryl hydrocarbon receptor | Homo sapiens |