Pub. Date : 2019 Nov 18
PMID : 31621310
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Many of the protective responses observed for flavonoids in the gastrointestinal track resemble aryl hydrocarbon receptor (AhR)-mediated effects. | Flavonoids | aryl hydrocarbon receptor | Homo sapiens |
| 2 | Many of the protective responses observed for flavonoids in the gastrointestinal track resemble aryl hydrocarbon receptor (AhR)-mediated effects. | Flavonoids | aryl hydrocarbon receptor | Homo sapiens |
| 3 | The structure-activity relationships for the flavonoids were complex and both response and cell context specific; however, there was significant variability in the AhR activities of the isomeric substituted isoflavones and flavones. | Flavonoids | aryl hydrocarbon receptor | Homo sapiens |
| 4 | These results coupled with simulation studies modeling flavonoid interaction within the AhR binding pocket demonstrate that the orientation of the substituted phenyl ring at C-2 (flavones) or C-3 (isoflavones) on the common 4-H-chromen-4-one ring strongly influences the activities of isoflavones and flavones as AhR agonists. | Flavonoids | aryl hydrocarbon receptor | Homo sapiens |
| 5 | These results coupled with simulation studies modeling flavonoid interaction within the AhR binding pocket demonstrate that the orientation of the substituted phenyl ring at C-2 (flavones) or C-3 (isoflavones) on the common 4-H-chromen-4-one ring strongly influences the activities of isoflavones and flavones as AhR agonists. | Flavonoids | aryl hydrocarbon receptor | Homo sapiens |