Pub. Date : 2019 Dec 1
PMID : 31606593
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Deletion of the serotonin transporter perturbs BDNF signaling in the central amygdala following long-access cocaine self-administration. | Cocaine | solute carrier family 6 member 4 | Rattus norvegicus |
| 2 | Additionally, while BDNF is strongly regulated by serotonin levels and inherited serotonin transporter down-regulation is associated with increased vulnerability to cocaine addiction, the effects of serotonin transporter genotype on BDNF signaling in the amygdala under naive and cocaine exposure conditions are unknown. | Cocaine | solute carrier family 6 member 4 | Rattus norvegicus |
| 3 | mBDNF protein expression and its signaling in cocaine-naive serotonin transporter knockout rats resembled that of wild-type rats with a history of long-access cocaine self-administration. | Cocaine | solute carrier family 6 member 4 | Rattus norvegicus |
| 4 | Interestingly, cocaine-exposed serotonin transporter knockout rats showed increased BDNF levels, with no signs of phospho-TrkB receptor coupling to phospho-Akt and phospho-ERK1. | Cocaine | solute carrier family 6 member 4 | Rattus norvegicus |