Title : Modulation of FLT3 signal transduction through cytoplasmic cysteine residues indicates the potential for redox regulation.

Pub. Date : 2020 Jan

PMID : 31606550






3 Functional Relationships(s)
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1 An underlying rationale was that the FLT3 gene is frequently mutated in Acute Myeloid Leukemia patients, and resulting oncogenic variants of FLT3 with "internal tandem duplications (FLT3ITD)" drive production of reactive oxygen in leukemic cells. Oxygen fms related receptor tyrosine kinase 3 Homo sapiens
2 An underlying rationale was that the FLT3 gene is frequently mutated in Acute Myeloid Leukemia patients, and resulting oncogenic variants of FLT3 with "internal tandem duplications (FLT3ITD)" drive production of reactive oxygen in leukemic cells. Oxygen fms related receptor tyrosine kinase 3 Homo sapiens
3 An underlying rationale was that the FLT3 gene is frequently mutated in Acute Myeloid Leukemia patients, and resulting oncogenic variants of FLT3 with "internal tandem duplications (FLT3ITD)" drive production of reactive oxygen in leukemic cells. Oxygen fms related receptor tyrosine kinase 3 Homo sapiens