Title : An Aldolase-Catalyzed New Metabolic Pathway for the Assimilation of Formaldehyde and Methanol To Synthesize 2-Keto-4-hydroxybutyrate and 1,3-Propanediol in Escherichia coli.

Pub. Date : 2019 Nov 15

PMID : 31603652






1 Functional Relationships(s)
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1 In addition to proof-of-concept we further improved the host strain by deleting a gene (frmA) responsible for the conversion of HCHO to formate, thereby increasing the production of 1,3-PDO from 298.3 +- 11.4 mg/L to 508.3 +- 9.1 mg/L and from 3.8 mg/L to 32.7 +- 0.8 mg/L with HCHO and methanol as co-substrate of glucose fermentation, respectively. 1,3-propanediol alcohol dehydrogenase class-III Escherichia coli