Pub. Date : 2019 Oct 8
PMID : 31597092
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The RNA-Binding Protein A1CF Regulates Hepatic Fructose and Glycerol Metabolism via Alternative RNA Splicing. | Fructose | APOBEC1 complementation factor | Mus musculus |
| 2 | Among these transcripts are isoforms for the dominant and high-affinity fructose-metabolizing ketohexokinase C and glycerol kinase, two key metabolic enzymes that are linked to hepatic gluconeogenesis and found to be markedly reduced upon hepatic ablation of A1cf. | Fructose | APOBEC1 complementation factor | Mus musculus |
| 3 | Consequently, mice lacking A1CF exhibit improved glucose tolerance and are protected from fructose-induced hyperglycemia, hepatic steatosis, and development of obesity. | Fructose | APOBEC1 complementation factor | Mus musculus |
| 4 | Our results identify a previously unreported function of A1CF as a regulator of alternative splicing of a subset of genes influencing hepatic glucose production through fructose and glycerol metabolism. | Fructose | APOBEC1 complementation factor | Mus musculus |