Pub. Date : 2019 Oct 8
PMID : 31594856
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Antibody-mediated blockade of GPIbalpha or of its receptor, Mac-1 integrin, inhibited the secretion of PGE2, IL-1beta, and IL-6 in MDP + Tc CM-activated monocytes, whereas recombinant GPIbalpha protein increased PGE2 production by MDP-treated monocytes. | Dinoprostone | integrin subunit alpha M | Homo sapiens |
| 2 | Antibody-mediated blockade of GPIbalpha or of its receptor, Mac-1 integrin, inhibited the secretion of PGE2, IL-1beta, and IL-6 in MDP + Tc CM-activated monocytes, whereas recombinant GPIbalpha protein increased PGE2 production by MDP-treated monocytes. | Dinoprostone | integrin subunit alpha M | Homo sapiens |
| 3 | Our findings suggest that the production of PGE2 and proinflammatory cytokines by MDP-activated monocytes is mediated by cooperation between two signaling pathways: one delivered by MDP through NOD2 and a second through activation of Mac-1 by T cell-derived GPIbalpha. | Dinoprostone | integrin subunit alpha M | Homo sapiens |