Title : RhoA-Dependent HGF and c-Met Mediate Gas6-Induced Inhibition of Epithelial-Mesenchymal Transition, Migration, and Invasion of Lung Alveolar Epithelial Cells.

Pub. Date : 2019 Oct 4

PMID : 31590238






2 Functional Relationships(s)
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1 The inhibition of the RhoA/Rho kinase pathway, using either a RhoA-targeted small interfering RNA (siRNA) or the Rho kinase pharmacologic inhibitor Y27362, prevented the inhibition of TGF-beta1-induced EMT in LA-4 cells and primary alveolar type II (AT II) epithelial cells. Yttrium transforming growth factor, beta 1 Mus musculus
2 Moreover, treatment with Y27362 or PHA-665752 prevented the Gas6-mediated inhibition of TGF-beta1-induced migration and invasion. Yttrium transforming growth factor, beta 1 Mus musculus