Title : Oncogenic Mutations Rewire Signaling Pathways by Switching Protein Recruitment to Phosphotyrosine Sites.

Pub. Date : 2019 Oct 3

PMID : 31585087






1 Functional Relationships(s)
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1 We demonstrated how mutations near tyrosine residues introduce molecular switches that rewire cancer signaling networks, and we revealed oncogenic properties of such a lung cancer EGFR mutant. Tyrosine epidermal growth factor receptor Homo sapiens