Title : Therapeutic effect of treatment with metformin and/or 4-hydroxychalcone in male Wistar rats with nonalcoholic fatty liver disease.

Pub. Date : 2019 Nov 15

PMID : 31563650






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Meanwhile in rats with NAFLD: i) metformin inhibited hepatic total cholesterol and TGF-beta, increased diarrhea frequency, and slightly decreased liver steatosis, and fibrosis; ii) 4-hydroxychalcone decreased IL-6, TNF-alpha and TGF-beta, increased IL-10, and markedly decreased liver steatosis and fibrosis; and iii) co-treatment markedly decreased food intake, total caloric intake, and body weight, increased diarrhea; increased IL-10, showing and intermediate effect on decrease TNF-alpha, TGF-beta, liver steatosis and fibrosis. Metformin interleukin 6 Rattus norvegicus