Pub. Date : 2019 Dec 1
PMID : 31563592
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Famotidine has a neuroprotective effect on MK-801 induced toxicity via the Akt/GSK-3beta/beta-catenin signaling pathway in the SH-SY5Y cell line. | Famotidine | glycogen synthase kinase 3 beta | Homo sapiens |
| 2 | A recent study based on computerized drug modeling software (docking) indicated that famotidine might inhibit the GSK3beta activity due to its chemical structure independent from histaminergic receptors. | Famotidine | glycogen synthase kinase 3 beta | Homo sapiens |
| 3 | In this study, we aimed to investigate the effects of famotidine on the Akt/GSK-3beta/beta-catenin signaling pathway on SH-SY5Y neuroblastoma cells in the presence of MK-801. | Famotidine | glycogen synthase kinase 3 beta | Homo sapiens |
| 4 | Pre-treatments with famotidine, olanzapine, and SB 415286 prevented MK-801 induced cell death via inhibitory effects on the MK-801 induced GSK-3beta activity. | Famotidine | glycogen synthase kinase 3 beta | Homo sapiens |
| 5 | Overall, the present results suggest that famotidine has a neuroprotective effect against MK-801 via modulation of the Akt/GSK-3beta/beta-catenin signaling pathway, an important mechanism in schizophrenia neurobiology. | Famotidine | glycogen synthase kinase 3 beta | Homo sapiens |