Pub. Date : 2020
PMID : 31556856
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Following Ca2+ depletion in the Endoplasmic reticulum (ER) store, STIM1 interacts with ORAI1 and leads to the opening of the CRAC channel gate and consequently allows the influx of Ca2+ ions. | Calcium | ORAI calcium release-activated calcium modulator 1 | Homo sapiens |
| 2 | Following Ca2+ depletion in the Endoplasmic reticulum (ER) store, STIM1 interacts with ORAI1 and leads to the opening of the CRAC channel gate and consequently allows the influx of Ca2+ ions. | Calcium | ORAI calcium release-activated calcium modulator 1 | Homo sapiens |
| 3 | A plethora of studies report that aberrant CRAC channel activity due to Loss- or gain-of-function mutations in ORAI1 and STIM1 disturbs this Ca2+ homeostasis and cause several autoimmune disorders. | Calcium | ORAI calcium release-activated calcium modulator 1 | Homo sapiens |