| Protein Name | ORAI calcium release-activated calcium modulator 1 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 84876 |
| Gene Symbol | ORAI1 |
| UniProt | Q96D31 (CRCM1_HUMAN), A0A024RBT3 (A0A024RBT3_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
238
Total Number of Articles : 444 |
Description |
ORAI calcium release-activated calcium modulator 1 |
| Gene Summary |
The protein encoded by this gene is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1). [provided by RefSeq, Sep 2011] |
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